On the cover, Dr. Lazarus' rank pips are on the left side of his collar instead of the right as they were in Galaxy Quest. Also, the laser gun held by Nesmith has the appearance of a 1930s-50s sci-fi laser gun, not the look of the weapons used on the show.

In the flashback sequence of the stage of Galaxy Quest Convention 18, the stage looks similar, but different, to that seen in Galaxy Quest; the podium is bigger, the announcer at the podium is not wearing glasses, the banners hanging at the back of the stage are different, the robot's body is different.

Notice that the fan dressed as a Tev'Meck in the audience in panel 1 of pages 2-3 appears to have braces on his teeth. 

The convention flashback scene of Brandon and his crew in panel 2 of pages 2-3 is similar to the scene in Galaxy Quest at 1:35:47 on the DVD except the clothing design is slightly different.

On page 3, Fred tells Laliari to stay behind at the convention as Colonel Stetson's troops take the rest of the crew away. She apparently is also left behind at Nesmith's house when Stetson returns to ask for the actors' help when the Judgement Ship arrives since she is seen still at the house at the beginning of issue #3 ("My Homeworld Away from Home"). It would seem the U.S. government/military is unaware that Jane Doe/Laliari is an alien.

After being taken into custody for questioning by the U.S. military, the crew finds themselves at Area 51. Area 51 is a top secret U.S. military base in the Nevada desert, suspected by some of housing the remains of extraterrestrials and the technology of their crashed ships.

As Guy is poked and prodded by a nurse at Area 51, he shouts, "Moon River!" "Moon River" is a song written by Johnny Mercer and Henry Mancini and sung by Audrey Hepburn in 1961 in the film Breakfast at Tiffany's. The nurse in this panel is using KY jelly to "search" him.

This issue reveals that the U.S. military came up with the explanation that the crash landing of the command disc at the Galaxy Quest convention was just a publicity stunt. The command disc was taken to Area 51 for study and storage.

The TV shows seen in panels 2-4 of page 6 appear to be thinly-disguised versions of the real world shows Inside the Actors Studio, The View, and You Can't Do That on Television, respectively. (You Can't Do That on Television was no longer airing new episodes during the time period of this story, having run from 1979-1990.)

On page 6, panel 5, a number of magazine covers are depicted. These appear to be Variety, Entertainment Weekly, and Vanity Fair. Peeple, a play on the actual magazine People, is also seen.

Throughout this issue, Fred is frequently seen grabbing a snack in the background, just as he did in Galaxy Quest.

This issue reveals that the command disc eventually repaired itself and forcibly ejects anybody but our six actors from entering.

On page 15, Fred is drinking coffee from a mug labeled USAF (United States Air Force).

On page 22, Colonel Stetson tells the crew, "...you are our last hope." This was also said by Mathasar to Nesmith in Galaxy Quest.